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1.
Ren Fail ; 45(1): 2205958, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37139725

RESUMO

BACKGROUND: The renal angina index (RAI) is a tool that has been validated by several studies in the pediatric population to predict the development of severe acute kidney injury (AKI). The aims of this study were to evaluate the efficacy of the RAI in predicting severe AKI in critically ill patients with COVID-19 and to propose a modified RAI (mRAI) for this population. METHODS: This was a prospective cohort analysis of all COVID-19 patients receiving invasive mechanical ventilation (IMV) who were admitted to the intensive care unit (ICU) of a third-level hospital in Mexico City from 03/2020 to 01/2021. AKI was defined according to KDIGO guidelines. The RAI score was calculated for all enrolled patients using the method of Matsuura. Since all patients had the highest score for the condition (due to receiving IMV), the score corresponded to the delta creatinine (ΔSCr) value. The main outcome was severe AKI (stage 2 or 3) at 24 and 72 h after ICU admission. A logistic regression analysis was applied to search for factors associated with the development of severe AKI, and the data were applied to develop a mRAI and compare it vis-à-vis the efficacy of both scores (RAI and mRAI). RESULTS: Of the 452 patients studied, 30% developed severe AKI. The original RAI score was associated with AUCs of 0.67 and 0.73 at 24 h and 72 h, respectively, with a cutoff of 10 points to predict severe AKI. In the multivariate analysis adjusted for age and sex, a BMI ≥30 kg/m2, a SOFA score ≥6, and Charlson score were identified as risk factors for the development of severe AKI. In the new proposed score (mRAI), the conditions were summed and multiplied by the ΔSCr value. With these modifications, the AUC improved to 0.72 and 0.75 at 24 h and 72 h, respectively, with a cutoff of 8 points. CONCLUSIONS: The original RAI is a limited tool for patients with critical COVID-19 receiving IMV. The mRAI, with the parameters proposed in the present study, improves predictive performance and risk stratification in critically ill patients receiving IMV.


Assuntos
Injúria Renal Aguda , COVID-19 , Humanos , Criança , Estado Terminal , Estudos Prospectivos , COVID-19/complicações , Unidades de Terapia Intensiva , Injúria Renal Aguda/etiologia , Injúria Renal Aguda/terapia , Injúria Renal Aguda/epidemiologia
2.
Artigo em Inglês | MEDLINE | ID: mdl-36767595

RESUMO

Wound care is an important public health challenge that is present in all areas of the healthcare system, whether in hospitals, long term care institutions or in the community. We aimed to quantify the number of skin wounds reported after and during the COVID-19 pandemic. This descriptive longitudinal retrospective study compared of wound records in patients hospitalized in the internal medicine service during the first year of the COVID-19 pandemic (from 1 March 2020, to 28 February 2021) and previous-year to the outbreak (from 1 January 2019, to 31 December 2019). A sample of 1979 episodes was collected corresponding to 932 inpatients, 434 from the pre-pandemic year and 498 from the first year of COVID-19 pandemic; 147 inpatients were diagnosed with SARS-CoV-2 infection (3.2%). The percentage of wound episodes in the first year of the COVID-19 pandemic was higher than the pre-pandemic year, 17.9% (1092/6090) versus 15% (887/5906), with a significant increase in the months with the highest incidence of COVID cases. This study shows an increase in the burden of wound care during the COVID-19 pandemic, and it could be attributable to the increase in the number of patients hospitalized for SARS-CoV-2 infection in internal medicine units.


Assuntos
COVID-19 , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Humanos , COVID-19/epidemiologia , Pandemias , SARS-CoV-2 , Estudos Retrospectivos , Estudos Longitudinais
3.
Adv Skin Wound Care ; 35(6): 1-7, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35426846

RESUMO

OBJECTIVE: To explore the clinical burden and epidemiologic profile of hospitalized patients with wounds during the first wave of COVID-19. METHODS: A retrospective and observational study was conducted to analyze the inpatient episodes of wound care in the University Hospital of Salamanca (Spain) during the initial COVID-19 crisis from March 1, 2020, to June 1, 2020. Data were collected from nursing care reports and clinical discharge reports. Included patients were 18 years or older, had a hospital length of stay of 1 day or longer, and were hospitalized in an internal medicine unit. Surgical and traumatic wounds and pediatric patients were excluded. RESULTS: A total of 116 patients and 216 wounds were included. The overall wound prevalence was 7.6%, and incidence was 3.5% in the internal medicine units. Pressure injuries (PIs) were the most common wound type, and patients with COVID-19 had significantly higher PI risk (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.1-4.0; P = .042). Significant differences in PI staging were noted: 83.2% of wounds in patients with COVID-19 were stages I-II versus 67.8% in patients without COVID-19; the probability of stage III-IV PIs among patients without COVID-19 was doubled (OR, 2.3; 95% CI, 1.2-4.5; P = .009). The probability of acute wounds tripled in patients with COVID-19 (OR, 3.7; 95% CI, 2.1-6.6; P < .001). Patients with COVID-19 also had longer mean hospital stays and higher ICU admission rates. No case fatality rate differences were observed. CONCLUSIONS: In this context of clinical practice, protocolized assessment and implementation of preventive measures must be ensured among older adult populations, patients with associated comorbidities, and ICU patients.


Assuntos
COVID-19 , Idoso , COVID-19/epidemiologia , Criança , Surtos de Doenças , Humanos , Pacientes Internados , Unidades de Terapia Intensiva , Estudos Retrospectivos , SARS-CoV-2
4.
PLoS One ; 17(2): e0263900, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35176083

RESUMO

BACKGROUND: Pressure Injuries (PIs) are major worldwide public health threats within the different health-care settings. OBJECTIVE: To describe and compare epidemiological and clinical features of PIs in COVID-19 patients and patients admitted for other causes in Internal Medicine Units during the first wave of COVID-19 pandemic. DESIGN: A descriptive longitudinal retrospective study. SETTING: This study was conducted in Internal Medicine Units in Salamanca University Hospital Complex, a tertiary hospital in the Salamanca province, Spain. PARTICIPANTS: All inpatients ≥18-year-old admitted from March 1, 2020 to June 1, 2020 for more than 24 hours in the Internal Medicine Units with one or more episodes of PIs. RESULTS: A total of 101 inpatients and 171 episodes were studied. The prevalence of PI episodes was 6% and the cumulative incidence was 2.9% during the first-wave of COVID-19. Risk of acute wounds was four times higher in the COVID-19 patient group (p<0.001). Most common locations were sacrum and heels. Among hospital acquired pressure injuries a significant association was observed between arterial hypertension and diabetes mellitus in patients with COVID-19 diagnosis. CONCLUSION: During the first wave of COVID-19, COVID-19 patients tend to present a higher number of acute wounds, mainly of hospital origin, compared to the profile of the non-COVID group. Diabetes mellitus and arterial hypertension were identified as main associated comorbidities in patients with COVID-19 diagnosis.


Assuntos
COVID-19/epidemiologia , Hospitalização/estatística & dados numéricos , Pacientes Internados/estatística & dados numéricos , Medicina Interna/estatística & dados numéricos , Úlcera por Pressão/fisiopatologia , SARS-CoV-2/isolamento & purificação , Idoso , Idoso de 80 Anos ou mais , COVID-19/patologia , COVID-19/virologia , Feminino , Seguimentos , Hospitais , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Prevalência , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Espanha/epidemiologia
5.
Brain Behav ; 11(12): e2415, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34758203

RESUMO

INTRODUCTION: Recent studies support the identification of valid subtypes within schizophrenia and bipolar disorder using cluster analysis. Our aim was to identify meaningful biotypes of psychosis based on network properties of the electroencephalogram. We hypothesized that these parameters would be more altered in a subgroup of patients also characterized by more severe deficits in other clinical, cognitive, and biological measurements. METHODS: A clustering analysis was performed using the electroencephalogram-based network parameters derived from graph-theory obtained during a P300 task of 137 schizophrenia (of them, 35 first episodes) and 46 bipolar patients. Both prestimulus and modulation of the electroencephalogram were included in the analysis. Demographic, clinical, cognitive, structural cerebral data, and the modulation of the spectral entropy of the electroencephalogram were compared between clusters. Data from 158 healthy controls were included for further comparisons. RESULTS: We identified two clusters of patients. One cluster presented higher prestimulus connectivity strength, clustering coefficient, path-length, and lower small-world index compared to controls. The modulation of clustering coefficient and path-length parameters was smaller in the former cluster, which also showed an altered structural connectivity network and a widespread cortical thinning. The other cluster of patients did not show significant differences with controls in the functional network properties. No significant differences were found between patients´ clusters in first episodes and bipolar proportions, symptoms scores, cognitive performance, or spectral entropy modulation. CONCLUSION: These data support the existence of a subgroup within psychosis with altered global properties of functional and structural connectivity.


Assuntos
Transtorno Bipolar , Transtornos Psicóticos , Esquizofrenia , Encéfalo/diagnóstico por imagem , Eletroencefalografia , Entropia , Humanos , Imageamento por Ressonância Magnética , Transtornos Psicóticos/psicologia
6.
Int Wound J ; 18(2): 209-220, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33236855

RESUMO

A systematic review and meta-analysis were conducted to clarify the effect of an early mobilisation programme on the prevention of hospital-acquired pressure injuries in an intensive care unit as opposed to standard care. We searched a total of 11 databases until 1 May 2020 and included seven studies (n = 7.520) related to the effect of early mobilisation protocol in the prevention of hospital-acquired pressure injuries (five quasi-experimental and two random comparative). The five quasi-experimental studies were significantly heterogeneous (P = .02 for Q test and 66% for I2 ), and the odds ratio was 0.97 (95% CI: 0.49-1.91) with a non-significant statistical difference between both groups (P = .93). Our study shows inconclusive outcomes related to the effect of the implementation of an early mobility programme in the prevention of pressure injuries in critical patients. Future research is needed considering the small number of articles on the topic.


Assuntos
Deambulação Precoce , Unidades de Terapia Intensiva , Úlcera por Pressão/prevenção & controle , Hospitais , Humanos , Estudos Retrospectivos
7.
Proc Natl Acad Sci U S A ; 117(51): 32423-32432, 2020 12 22.
Artigo em Inglês | MEDLINE | ID: mdl-33288712

RESUMO

Gentamicin is a potent broad-spectrum aminoglycoside antibiotic whose use is hampered by ototoxic side-effects. Hospital gentamicin is a mixture of five gentamicin C-subtypes and several impurities of various ranges of nonexact concentrations. We developed a purification strategy enabling assaying of individual C-subtypes and impurities for ototoxicity and antimicrobial activity. We found that C-subtypes displayed broad and potent in vitro antimicrobial activities comparable to the hospital gentamicin mixture. In contrast, they showed different degrees of ototoxicity in cochlear explants, with gentamicin C2b being the least and gentamicin C2 the most ototoxic. Structure-activity relationships identified sites in the C4'-C6' region on ring I that reduced ototoxicity while preserving antimicrobial activity, thus identifying targets for future drug design and mechanisms for hair cell toxicity. Structure-activity relationship data suggested and electrophysiological data showed that the C-subtypes both bind and permeate the hair cell mechanotransducer channel, with the stronger the binding the less ototoxic the compound. Finally, both individual and reformulated mixtures of C-subtypes demonstrated decreased ototoxicity while maintaining antimicrobial activity, thereby serving as a proof-of-concept of drug reformulation to minimizing ototoxicity of gentamicin in patients.


Assuntos
Antibacterianos/farmacologia , Cóclea/efeitos dos fármacos , Gentamicinas/efeitos adversos , Gentamicinas/química , Gentamicinas/farmacologia , Animais , Antibacterianos/efeitos adversos , Antibacterianos/química , Antibacterianos/isolamento & purificação , Cóclea/citologia , Contaminação de Medicamentos , Gentamicinas/isolamento & purificação , Células Ciliadas Auditivas/efeitos dos fármacos , Hospitais , Canais Iônicos/metabolismo , Mecanotransdução Celular/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Ratos Sprague-Dawley , Sisomicina/farmacologia , Relação Estrutura-Atividade
8.
BMC Infect Dis ; 18(1): 306, 2018 07 05.
Artigo em Inglês | MEDLINE | ID: mdl-29976137

RESUMO

BACKGROUND: Cystic echinococcosis (CE) is a well-known neglected parasitic disease. However, evidence supporting the four current treatment modalities is inadequate, and treatment options remain controversial. The aim of this work is to analyse the available data to answer clinical questions regarding medical treatment of CE. METHODS: A thorough electronic search of the relevant literature without language restrictions was carried out using PubMed (Medline), Cochrane Central Register of Controlled Trials, BioMed, Database of Abstracts of Reviews of Effects, and Cochrane Plus databases up to February 1, 2017. All descriptive studies reporting an assessment of CE treatment and published in a peer-reviewed journal with available full-text were considered for a qualitative analysis. Randomized controlled trials were included in a quantitative meta-analysis. We used the standard methodological procedures established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. RESULTS: We included 33 studies related to the pharmacological treatment of CE in humans. Of these, 22 studies with levels of evidence 2 to 4 were qualitatively analysed, and 11 randomized controlled trials were quantitatively analysed by meta-analysis. CONCLUSIONS: Treatment outcomes are better when surgery or PAIR (Puncture, Aspiration, Injection of protoscolicidal agent and Reaspiration) is combined with benzimidazole drugs given pre- and/or post-operation. Albendazole chemotherapy was found to be the primary pharmacological treatment to consider in the medical management of CE. Nevertheless, combined treatment with albendazole plus praziquantel resulted in higher scolicidal and anti-cyst activity and was more likely to result in cure or improvement relative to albendazole alone.


Assuntos
Albendazol/uso terapêutico , Anti-Helmínticos/uso terapêutico , Benzimidazóis/uso terapêutico , Equinococose/tratamento farmacológico , Doenças Negligenciadas/tratamento farmacológico , Praziquantel/uso terapêutico , Bases de Dados Factuais , Quimioterapia Combinada , Equinococose/cirurgia , Humanos , Doenças Negligenciadas/parasitologia , Doenças Negligenciadas/cirurgia , Resultado do Tratamento
9.
Front Cell Neurosci ; 11: 325, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29093664

RESUMO

Aminoglycosides are potent antibiotics deployed worldwide despite their known side-effect of sensorineural hearing loss. The main etiology of this sensory deficit is death of inner ear sensory hair cells selectively triggered by aminoglycosides. For decades, research has sought to unravel the molecular events mediating sensory cell demise, emphasizing the roles of reactive oxygen species and their potentials as therapeutic targets. Studies in recent years have revealed candidate transport pathways including the mechanotransducer channel for drug entry into sensory cells. Once inside sensory cells, intracellular targets of aminoglycosides, such as the mitochondrial ribosomes, are beginning to be elucidated. Based on these results, less ototoxic aminoglycoside analogs are being generated and may serve as alternate antimicrobial agents. In this article, we review the latest findings on mechanisms of aminoglycoside entry into hair cells, their intracellular actions and potential therapeutic targets for preventing aminoglycoside ototoxicity.

10.
BMC Infect Dis ; 17(1): 455, 2017 06 27.
Artigo em Inglês | MEDLINE | ID: mdl-28655301

RESUMO

BACKGROUND: Cystic echinococcosis (CE) is a chronic, complex and neglected zoonotic disease. CE occurs worldwide. In humans, it may result in a wide spectrum of clinical manifestations, ranging from asymptomatic infection to fatal disease. Clinical management procedures have evolved over decades without adequate evaluation. Despite advances in surgical techniques and the use of chemotherapy, recurrence remains one of the major problems in the management of hydatid disease. The aim of this study was to determine the frequency of CE recurrence and the risk factors involved in recurrence. METHODS: A descriptive longitudinal-retrospective study was designed. We reviewed all patients diagnosed with CE according to ICD-9 (code 122-0 to 122-9) criteria admitted at Complejo Asistencial Universitario de Salamanca, Spain, between January 1998 and December 2015. RESULTS: Among the 217 patients studied, 25 (11.5%) had a hydatid recurrence after curative intention treatment. Median duration of recurrence's diagnosis was 12.35 years (SD: ±9.31). The likelihood of recurrence was higher [OR = 2.7; 95% CI, 1.1-7.1; p < 0.05] when the cyst was located in organs other than liver and lung, 22.6% (7/31) vs 14.2% (31/217) in the cohort. We detected a chance of recurrence [OR = 2.3; 95% CI, 1.4-6.5; p > 0.05] that was two times higher in those patients treated with a combination of antihelminthic treatments and surgical intervention (20/141, 14.2%) than in patients treated with surgical intervention alone (5/76, 6.6%). CONCLUSIONS: Despite advances in diagnosis and therapeutic techniques in hydatid disease, recurrence remains one of the major problems in the management of hydatid disease. The current management and treatment of recurrences is still largely based on expert opinion and moderate-to-poor quality of evidence. Consequently, large prospective and multicenter studies will be needed to provide definitive recommendations for its clinical management.


Assuntos
Anti-Helmínticos/uso terapêutico , Equinococose/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Criança , Pré-Escolar , Equinococose/tratamento farmacológico , Equinococose/etiologia , Equinococose/mortalidade , Feminino , Humanos , Estimativa de Kaplan-Meier , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Recidiva , Estudos Retrospectivos , Fatores de Risco , Espanha
11.
Enferm. infecc. microbiol. clín. (Ed. impr.) ; 34(4): 232-236, abr. 2016. mapas, graf, tab
Artigo em Espanhol | IBECS | ID: ibc-151988

RESUMO

INTRODUCCIÓN: La hidatidosis humana es una zoonosis con distribución cosmopolita. Todavía constituye un importante problema de salud pública en muchas regiones del mundo, incluida la cuenca mediterránea. La situación epidemiológica actual no es conocida en ciertas regiones de España. El objetivo de este trabajo es renovar los datos epidemiológicos de la hidatidosis en pacientes hospitalizados en el sistema público de salud de Extremadura. MÉTODOS: Estudio descriptivo longitudinal y retrospectivo de pacientes hospitalizados con diagnóstico de hidatidosis (códigos CIE 122.0-122.9) en centros sanitarios del sistema público de salud de Extremadura durante el periodo 2003-2012. RESULTADOS: Se incluyeron 876 pacientes con diagnóstico de hidatidosis; 536 (61%) fueron varones, con una edad media de 65,5 ± 17,8; 19 casos (2,2%) fueron menores de 19 años: 17 (89,47%) casos entre los años 2003-2007 versus 2 casos entre 2008-2012 (OR = 7,83; IC 95%: 1,79-34,11; p = 0,001). Un total de 141 (16,0%) eran menores de 45 años. El diagnóstico primario fue más frecuente en menores de 45 años y el diagnóstico secundario más frecuente en mayores de 70 años (p < 0,05). La tasa de incidencia fue mayor a través del registro de pacientes hospitalizados (8,02 casos por 105 personas-año) respecto al sistema de declaración obligatoria de enfermedades (1,88 casos por 105 personas-año), p < 0,05. CONCLUSIÓN: En Extremadura la hidatidosis es todavía frecuente, con una clara disminución en el número de casos pediátricos. El número de casos obtenidos mediante los registros de pacientes hospitalizados respecto al sistema de notificación de enfermedades de Extremadura sugieren la necesidad de modificaciones que mejoren la vigilancia y el control de la hidatidosis


INTRODUCTION: Echinococcosis is a zoonotic infection with a worldwide distribution, and is still an important health problem in many areas of the world, including the Mediterranean basin. At present the epidemiological situation is unclear in certain regions of Spain. The aim of this study was to update the epidemiological situation in Extremadura through an analysis of hospitalised patients in the public health system diagnosed with hydatid disease. METHODS: A longitudinal retrospective study was conducted between 2003 and 2012 on hospitalised patients with a diagnosis of hydatidosis (ICD 122.0-122.9) in hospitals of the public health service of Extremadura. RESULTS: During the period of study, 876 patients were diagnosed with hydatid disease. Of these 536 (61%) of cases were male, with a mean age of 65.53 ± 17.8 years. More importantly, 19 (2.2%) of patients were 19 years old, with 17 cases between 2003-2007 versus 2 cases between 2008-2012 (OR = 7.83; 95% CI: 1.79-34.11; P = .001). A total of 141 (16.0%) were younger than 45 years. The primary diagnosis was most frequently reported in the younger population < 45 years, whereas the secondary diagnosis was usually found in the elderly population > 70 years (P < .05). The incidence rate of hydatid disease obtained from Hospital Discharge Records (HDRs) was significantly higher compared to the incidence that was declared in the Notifiable Disease System of Extremadura (8.02 cases per 105 person-years vs. 1.88 cases per 105 person-years [P < .05]). CONCLUSION: In Extremadura hydatid disease is still frequent. With a clear decrease in the number of paediatric cases. The number of cases obtained from HDRs regarding Notification System Diseases Extremadura suggests the need for modifications to improve surveillance and control of hydatid disease


Assuntos
Humanos , Equinococose/epidemiologia , Echinococcus granulosus/isolamento & purificação , Anti-Helmínticos/uso terapêutico , Helmintíase/epidemiologia , Hospitalização/estatística & dados numéricos
12.
Trans R Soc Trop Med Hyg ; 110(11): 664-669, 2016 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-28115684

RESUMO

BACKGROUND: In Spain, 12% of the population are immigrants. The impact of immigration in Spain on cystic echinococcosis (CE) is unknown. The aim of this study was to describe the epidemiology of CE in immigrants in western Spain. METHODS: First, a retrospective descriptive study of patients diagnosed with CE in the University Hospital of Salamanca (CAUSA) between January 1998 and December 2014 was designed. Second, we studied the seroprevalence of CE in sera from foreigners who received treatment in the Tropical Medicine Unit. RESULTS: A total of 550 patients with new CE-related diagnoses were registered; of these, 16 (2.9%) were immigrants, of whom 10 (63%) were male. The age (mean±SD) was 34.6±12.8 years. The incidence rate of CE in immigrants was 8.76 cases per 105 person-years. Eight (50%) cases presented asymptomatically. Seroprevalence of CE in foreign patients was 2.3%. It was higher in North African population (4.2%), followed by sub-Saharan (2.4%) and Latin American (1.8%) (p=0.592) populations. The seroprevalence was higher in those who arrived recently (<12 months) vs those who arrived earlier (≥12 months), 3.5% vs 1.3% (p=0.077). CONCLUSIONS: The epidemiological and clinical characteristics of CE in immigrants are different than those of the native population, and their influence on CE burden in our endemic area is still limited.


Assuntos
Equinococose , Equinococose/epidemiologia , Emigrantes e Imigrantes , Humanos , Incidência , Estudos Retrospectivos , Espanha/epidemiologia
13.
Enferm Infecc Microbiol Clin ; 34(4): 232-6, 2016 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-26220501

RESUMO

INTRODUCTION: Echinococcosis is a zoonotic infection with a worldwide distribution, and is still an important health problem in many areas of the world, including the Mediterranean basin. At present the epidemiological situation is unclear in certain regions of Spain. The aim of this study was to update the epidemiological situation in Extremadura through an analysis of hospitalised patients in the public health system diagnosed with hydatid disease. METHODS: A longitudinal retrospective study was conducted between 2003 and 2012 on hospitalised patients with a diagnosis of hydatidosis (ICD 122.0-122.9) in hospitals of the public health service of Extremadura. RESULTS: During the period of study, 876 patients were diagnosed with hydatid disease. Of these 536 (61%) of cases were male, with a mean age of 65.53±17.8 years. More importantly, 19 (2.2%) of patients were 19 years old, with 17 cases between 2003-2007 versus 2 cases between 2008-2012 (OR=7.83; 95%CI: 1.79-34.11; P=.001). A total of 141 (16.0%) were younger than 45 years. The primary diagnosis was most frequently reported in the younger population <45 years, whereas the secondary diagnosis was usually found in the elderly population >70 years (P<.05). The incidence rate of hydatid disease obtained from Hospital Discharge Records (HDRs) was significantly higher compared to the incidence that was declared in the Notifiable Disease System of Extremadura (8.02 cases per 10(5) person-years vs. 1.88 cases per 10(5) person-years [P<.05]). CONCLUSION: In Extremadura hydatid disease is still frequent. With a clear decrease in the number of paediatric cases. The number of cases obtained from HDRs regarding Notification System Diseases Extremadura suggests the need for modifications to improve surveillance and control of hydatid disease.


Assuntos
Equinococose/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Animais , Feminino , Hospitalização , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Saúde Pública , Estudos Retrospectivos , Espanha/epidemiologia , Zoonoses/epidemiologia
14.
PLoS Negl Trop Dis ; 9(10): e0004154, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26484764

RESUMO

BACKGROUND: Cystic echinococcosis (CE) is an important health problem in many areas of the world including the Mediterranean region. However, the real CE epidemiological situation is not well established. In fact, it is possible that CE is a re-emerging disease due to the weakness of current control programs. METHODOLOGY: We performed a retrospective observational study of inpatients diagnosed with CE from January 2000 to December 2012 in the Western Spain Public Health-Care System. PRINCIPAL FINDINGS: During the study period, 5510 cases of CE were diagnosed and 3161 (57.4%) of the cases were males. The age mean and standard deviation were 67.8 ± 16.98 years old, respectively, and 634 patients (11.5%) were younger than 45 years old. A total of 1568 patients (28.5%) had CE as the primary diagnosis, and it was most frequently described in patients <45 years old. Futhermore, a secondary diagnosis of CE was usually found in patients >70 year old associated with other causes of comorbidity. The period incidence rate was 17 cases per 105 person-years and was significantly higher when compared to the incidence declared through the Notifiable Disease System (1.88 cases per 105 person-years; p<0.001). CONCLUSIONS: CE in western Spain is an underestimated parasitic disease. It has an active transmission, with an occurrence in pediatric cases, but has decreased in the recent years. The systematic search of Hospital Discharge Records of the National Health System Register (HDR) may be a more accurate method than other methods for the estimation of the incidence of CE in endemic areas.


Assuntos
Equinococose/epidemiologia , Monitoramento Epidemiológico , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Lactente , Masculino , Região do Mediterrâneo/epidemiologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Distribuição por Sexo , Espanha/epidemiologia , Adulto Jovem
15.
PLoS One ; 9(3): e91342, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24632824

RESUMO

BACKGROUND: Cystic hydatid disease is still an important health problem in European Mediterranean areas. In spite of being traditionally considered as a "benign" pathology, cystic echinococcosis is an important cause of morbidity in these areas. Nevertheless, there are few analyses of mortality attributed to human hydatidosis. OBJECTIVE: To describe the epidemiology, the mortality rate and the causes of mortality due to E. granulosus infection in an endemic area. METHODOLOGY: A retrospective study followed up over a period of 14 years (1998-2011). PRINCIPAL FINDINGS: Of the 567 patients diagnosed with hydatid disease over the period 1998-2011, eleven deaths directly related to hydatid disease complications were recorded. Ten patients (90.9%) died due to infectious complications and the remaining one (9.1%) died due to mechanical complications after a massive hemoptysis. We registered a case fatality rate of 1.94% and a mortality rate of 3.1 per 100.000 inhabitants. CONCLUSIONS: Hydatidosis is still a frequent parasitic disease that causes a considerable mortality. The main causes of mortality in patients with hydatidosis are complications related to the rupture of CE cysts with supurative collangitis. Therefore, an expectant management can be dangerous and it must be only employed in well-selected patients.


Assuntos
Equinococose/epidemiologia , Adulto , Idoso , Animais , Causas de Morte , Equinococose/mortalidade , Echinococcus granulosus , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Morbidade , Razão de Chances , Estudos Retrospectivos , Espanha
16.
Clin Med (Lond) ; 13(2): 141-5, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23681860

RESUMO

Fever of unknown origin (FUO) is an entity caused by more than 200 diseases. Haematologic neoplasms are the most common malignant cause of FUO. Fever as a first symptom of colonic tumour pathology, both benign and malignant, is a rare form of presentation. Our work is a descriptive study of a series of 23 patients with colonic tumoral pathology who presented with fever of unknown origin. The mean age was 67.6 years; 56.5% of patients were men and 43.5% were women. Primary malignant neoplasia was the most common diagnosis. Blood cultures were positive in 45% of the samples. Coagulase-negative staphylococci were the most common cause of bacteraemia. Nine of 10 faecal occult blood tests performed were positive. Fever secondary to colon neoplasms, both benign and malignant, usually presents with a bacteraemic pattern, with positive results for blood-culture tests in a high percentage of cases.


Assuntos
Bacteriemia/complicações , Neoplasias do Colo/complicações , Neoplasias do Colo/diagnóstico , Febre de Causa Desconhecida/etiologia , Sangue Oculto , Adulto , Idoso , Idoso de 80 Anos ou mais , Anemia/etiologia , Anorexia/etiologia , Astenia/etiologia , Bacteriemia/microbiologia , Doença Crônica , Pólipos do Colo/complicações , Pólipos do Colo/diagnóstico , Infecções por Escherichia coli/complicações , Feminino , Humanos , Masculino , Infecções Estafilocócicas/complicações , Infecções Estafilocócicas/microbiologia , Redução de Peso
17.
Rev. latinoam. psicol ; 45(2): 241-252, mayo-ago. 2013.
Artigo em Espanhol | LILACS | ID: lil-691202

RESUMO

Se realiza una visión de la Psicología de la Salud en tres grandes momentos. Uno inicial que se puede denominar como profesional, en el que los psicólogos se introducen en el campo de la salud, junto a los profesionales de la medicina y desarrollan un campo específico, intentando relacionar aspectos psicológicos con aspectos biomédicos. Un segundo momento, que denominamos lego, en el sentido de que la salud se convierte en un tema de responsabilidad de las personas. A niveles académicos coincide con la construcción social de la salud como enfoque dominante. Por último, un tercer momento que está en marcha actualmente, es la homogeneización o esquemas de integración de los servicios de salud. Hoy la cuestión central es integrar las políticas sanitarias de la mayoría de los países por medio de actuaciones colectivas y globales; según los planes internacionales exigidos por la globalización.


This paper conveys a vision of health psychology in three great moments. The first can be called a professional moment, wherein psychologists are introduced to the health field along with medical professionals, and develop a specific field, thereby trying to relate biomedical aspects to psychological ones. A second, or naïve moment means that health becomes an issue of responsibility of individuals. At academic levels, this coincides with the social construction of health as a dominant approach. Finally, a currently ongoing third stage is health service homogenization or integration. The main issue today is to integrate health policies of most countries through both collective and global action, as per international plans demanded by globalization.

19.
Psicothema (Oviedo) ; 24(3): 442-448, jul.-sept. 2012. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-100692

RESUMO

Toda sociedad desarrolla un sistema concreto de creencias que resume su visión de la organización sociopolítica, la cultura y las relaciones interpersonales. Cada una de estas tres dimensiones básicas adopta formas muy diferentes según el contexto espacial y temporal de las sociedades. El Sistema de Creencias de las sociedades de servicios se caracteriza por una visión democrática de la organización social y política, cierto rechazo de los cambios sociales radicales y altos niveles de confianza interpersonal. En este trabajo se analiza empíricamente la incorporación y adaptación del Sistema de Creencias Postmodernas en una muestra de estudiantes universitarios, pertenecientes a un país que está integrándose lentamente en la sociedad de servicios. Se utilizó una escala de postmodernidad para analizar la incorporación del sistema de creencias postmodernas. Los resultados indican que existe una combinación peculiar de las tres dimensiones básicas del Sistema de Creencias Postmodernas, donde la concepción postmoderna de la cultura y las relaciones sociales tienen una menor aceptación (AU)


Every society develops a particular system of beliefs that summarizes its vision of socio-political organization, culture and interpersonal relationships. Each of these three basic dimensions has different forms, depending on the spatial and temporal context of societies. The belief system of the service societies is characterized by a democratic vision of social and political organization, rejection of radical social changes and high levels of interpersonal trust. This paper empirically examines the incorporation and adaptation of the postmodern belief system in a sample of university students. The participants belong to a country that is slowly integrating into the service societies. We used a scale of postmodernity to analyze the incorporation of the postmodern belief system. The results indicate that there is a peculiar combination of the three basic dimensions of the postmodern belief system, where the postmodern conceptions of culture and social relationships have lower acceptance (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Religião e Psicologia , Relações Interpessoais , Diversidade Cultural , Rede Social , Relativismo Ético
20.
Psicothema ; 24(3): 442-8, 2012.
Artigo em Espanhol | MEDLINE | ID: mdl-22748738

RESUMO

Every society develops a particular system of beliefs that summarizes its vision of socio-political organization, culture and interpersonal relationships. Each of these three basic dimensions has different forms, depending on the spatial and temporal context of societies. The belief system of the service societies is characterized by a democratic vision of social and political organization, rejection of radical social changes and high levels of interpersonal trust. This paper empirically examines the incorporation and adaptation of the postmodern belief system in a sample of university students. The participants belong to a country that is slowly integrating into the service societies. We used a scale of postmodernity to analyze the incorporation of the postmodern belief system. The results indicate that there is a peculiar combination of the three basic dimensions of the postmodern belief system, where the postmodern conceptions of culture and social relationships have lower acceptance.


Assuntos
Pós-Modernismo , Estudantes/psicologia , Adolescente , Cultura , Democracia , Ética , Feminino , Humanos , Relações Interpessoais , Estilo de Vida , Masculino , Autonomia Pessoal , Mudança Social , Valores Sociais , Espanha , Inquéritos e Questionários , Tecnologia , Universidades , Adulto Jovem
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